Insulin sensitivity measured by insulin-stimulated glucose Rd was significantly different between each group (Ath: 12.4 ± 0.6, Lean: 8.8 ± 0.7, Ob: 5.1 ± 0.6, and T2D: 2.4 ± 0.4 mg/kg/min; P < 0.0001). This evidence concerns the gene INS and type 2 diabetes mellitus.