Dedicator of cytokinesis protein 7 (DOCK7), which is localized to the developing axons, activates Rac1 and Rac3 small GTPases and regulates neuronal polarity; moreover, its variants cause developmental and epileptic encephalopathy 23 (DEE23) (77, 78). The gene discussed is RAC3; the disease is genetic developmental and epileptic encephalopathy.