Apart from their physiological functions, Kv10.1 channels are markedly up-regulated in many cancer cells such as melanomas, breast carcinomas, soft-tissue sarcoma, cervical carcinoma, neuroblastomas, gliomas, gastric and colorectal cancer, esophageal squamous cell carcinomas, and hepatocellular carcinoma15–23. The gene discussed is KCNH1; the disease is cancer.