Furthermore, immunohistochemical expression of TRAF6 protein in the LV was significantly elevated in the CH group compared to the Control group (p < 0.001) (Fig. 2A–C) and significantly downregulated by LCZ696 and VAL compared to the CH group (p < 0.001) (Fig. 2A–C). This evidence concerns the gene TRAF6 and cyclic hematopoiesis.