Moreover, the HW/BW ratio was also significantly higher in CH group rats than controls (p < 0.05) (Fig. 1E–G), as were serum concentrations of the cardiac hypertrophy markers NT-pro BNP and FGF-23 (both p < 0.001) (Fig. 1A, B). This evidence concerns the gene NPPB and cyclic hematopoiesis.