On this basis, we conducted a cytokine multiplex assay and found that mice displaying a more aggressive MDS phenotype presented higher pro-inflammatory cytokines levels (IFN-γ, IL-6, IL-10, and TNF-α), suggesting a contributing role of inflammation in Zrsr2m/mTet2−/− MDS phenotype (Supplementary Fig. 6). The gene discussed is TNF; the disease is myelodysplastic syndrome.