We finally observed that upregulated CLEC2B expression was remarkably associated with poor OS in 10 tumor types (GBMLGG, KIPAN, LGG, KIRC, LAML, PAAD, GBM, UVM, MESO, TGCT) and downregulated expression was correlated with poor OS in 2 tumor type (SKCM and ALL). Here, CLEC2B is linked to acute lymphoblastic leukemia.