CDKN1A and Hyperglycemia: Using a model of type 2 diabetes mellitus (T2DM; db/db mice) and a similar experimental set up (persistent hyperglycemia until age 16 weeks followed by reduction of blood glucose levels using SGLT2i; Supplementary Fig. 2a–c), we likewise observed sustained albuminuria (Supplementary Fig. 2d) in association with persistent p21 induction in renal cortex extracts (Fig. 2b, Supplementary Fig. 2e).