Analyses of human kidney tissue and peripheral blood monocytes identified hypomethylation and increased expression of other genes previously linked with DKD, such as the integrin β2, genes related to TNF signaling and the redox-regulator TXNIP, corroborating that DNA hypomethylation contributes to the persistent expression of genes linked with diabetic vascular complications44,45. The gene discussed is TXNIP; the disease is diabetic kidney disease.