Using a model of type 2 diabetes mellitus (T2DM; db/db mice) and a similar experimental set up (persistent hyperglycemia until age 16 weeks followed by reduction of blood glucose levels using SGLT2i; Supplementary Fig. 2a–c), we likewise observed sustained albuminuria (Supplementary Fig. 2d) in association with persistent p21 induction in renal cortex extracts (Fig. 2b, Supplementary Fig. 2e). Here, CDKN1A is linked to type 2 diabetes mellitus.