Specific inhibitors of PARP14 catalytic activity have recently been developed, and targeting PARP14 has been proposed as a possible therapeutic approach for multiple cancer types including pancreatic, hepatic and multiple melanoma, since pro-survival/proliferation and anti-apoptotic activities of PARP14 have been described in these cancers10,13,14,16–18. This evidence concerns the gene PARP14 and cancer.