BRCA1 and breast carcinoma: In addition, PARP14 depletion suppressed olaparib and cisplatin-induced apoptosis in RPE1-BRCA1KO cells (Supplementary Fig. 2e, f), as well as the cisplatin sensitivity of MDA-MB-436 patient-derived BRCA1-mutant breast cancer cells (Supplementary Fig. 2g).