SIRT1 and obesity due to melanocortin 4 receptor deficiency: SIRT1 may protect PCOS patients, mainly through oxidative stress, inhibition of granular cell autophagy, improvement of mitochondrial dysfunction, abnormal improvement of ovulation disorders (enhanced quality of oocyte and embryo), improvement of the hormone metabolism disorder (lower testosterone levels), and a certain degree in improvement of its complications: obesity and lipid metabolic disorder.