Studies have shown that the levels of AMPK (the key regulator of the mitochondrial response to energy deprivation) and SIRT1 in the ovaries of PCOS rats are significantly lower than the levels of AMPK of the control group, and they are in an obvious IR state, which is the same as in PCOS mice [57–59]. The gene discussed is SIRT1; the disease is polycystic ovary syndrome.