Our previous study suggested that colon cancer cells with neuroendocrine differentiation induce the infiltration of tumor-associated macrophages (TAMs) by increasing the expression of CXCL10 and CXCL11, thus the proliferation and invasiveness of CRC were intensified [5], while the specific molecular pathway involved have not been elucidated. This evidence concerns the gene CXCL10 and neoplasm.