In this study, we further illustrated that exosome-derived lnc-HOXB8-1:2 induced the migration and invasion of TAMs to promote the development of colon adenocarcinoma with neuroendocrine differentiation via sponging hsa-miR-6825-5p to upregulate CXCR3 expression. Here, HOXB8 is linked to colon adenocarcinoma.