CXCR3+ NK-cell and CD8+ T-cell tumoral infiltration, directed by CXCL9 and CXCL10, can delay primary tumor growth in MC38 colon carcinoma and TC-1 epithelial carcinoma mouse models when treated with heterodimeric IL-15 [32]. This evidence concerns the gene CXCL9 and colon carcinoma.