TGFB1 and colorectal carcinoma: Exosome-derived CircPACRGL manipulated TGF-β expression by sponging miR-142-3p/miR-506-3p to induce N1-N2 neutrophil differentiation, resulting in CRC proliferation and migration [15], whereas lncRNA-PVT1 acted as a competitive inhibitor of miR-455 to downregulate miR-455 and ultimately promote the progression of CRC [34].