These results suggested that exosome-derived lnc-HOXB8-1:2 acted as a ceRNA of hsa-miR-6825-5p to decrease its level as well as impair its activity so that CXCR3 expression was positively regulated, thus promoting TAM infiltration and M2 polarization and, eventually leading to the advancement of neuroendocrine differentiated CRC. This evidence concerns the gene HOXB8 and colorectal carcinoma.