Collectively, in this study, colon cancer cells with NED released CXCL10 and CXCL11 to recruit CXCR3+ TAMs and promote their differentiation into M2 macrophages, favoring tumor progression that demonstrated the tumor-promoting function of CXCR3 and its ligands, CXCL10 and CXCL11, which differed from the findings mentioned above. The gene discussed is CXCL10; the disease is malignant colon neoplasm.