Hippocampal injury and inflammation highlighted by pyknotic neuronal cells [77], activation of microglial cells [13], upregulation of toll-like receptor-4 [78], increased levels of keratinocyte-derived chemokine, and increased levels of granulocyte colony-stimulating factor [79] within the hippocampus of renal ischemia reperfusion injury-induced AKI mouse models provide further evidence for a direct pathological role for AKI in delirium. The gene discussed is TLR4; the disease is acute kidney injury.