RIPK3 and type 1 diabetes mellitus: Although the current study was focused on type-1 diabetes, we speculate that cardiomyocyte necroptosis may also play a role in cardiac pathology of type-2 diabetes as the necroptosis signaling RIPK3 and MLKL were activated in the heart of db/db type-2 diabetic mice [27] and high fat diet plus STZ-induced type-2 diabetic rats [43].