Both had T2DM and established ASCVD, but those in ACCORD had more prior MI, heart failure, coronary artery bypass grafting, carotid stenosis, higher HbA1c, more insulin use, and higher eGFR, whereas TECOS had higher atrial fibrillation, high-density lipoprotein cholesterol, diastolic blood pressure, heart rate, and chronic kidney disease. The gene discussed is INS; the disease is atherosclerosis.