Our data are consistent with recent work showing that JAGGED‐1 elicits Th2 responses, thus stimulating the airway inflammation (Tindemans et al., 2017), and in nasal polyps epithelial cells the JAGGED‐1 mediated activation of Notch signaling increases nuclear and cytoplasmic levels of IL‐33 (Chiappara et al., 2019). This evidence concerns the gene IL33 and nasal cavity polyp.