In the 4th wave of the COVID‐19 pandemic, AstraZeneca single vaccinated COVID‐19 patients had a higher CRP (7.45 ± 3.99) than AstraZeneca double vaccinated COVID‐19 patients (2.68 ± 2.01, pv < 0.0001), Pfizer single (2.68 ± 2.01, pv < 0.0001) and double (2.59 ± 1.75, pv < 0.0001) vaccinated COVID‐19 patients. This evidence concerns the gene CRP and COVID-19.