LDLR and cancer: In this study, nano-LDL particles are used as an active drug delivery platform to transport anticancer agents into the middle of cancer cells mimicking the native LDL metabolic pathway, mimicking the amino acids functional groups, the shape of agents, the size of the agents before and after encapsulation with nano-LDL particles, then LDL particles internalization through highly expressing LDL-receptors cancer cells targeting microtubule function.