Furthermore, research studies showed that LDL-receptors are highly expressed in cancer cells more than in healthy cells (Song et al., 2009; Alhadad et al., 2020; Jaragh Alhadad, 2021) and induce cancer cell proliferation (Antalis et al., 2010; Gallagher et al., 2017), metastasis, and angiogenesis (Lu et al., 2017; Zhang et al., 2021; Tsumita et al., 2022). This evidence concerns the gene LDLR and cancer.