It is important to note that LDL-receptors are highly expressed in cancer cells more than in benign cells and this provides a good mechanism for internalization, drug concentration, and accumulation in the targeted cells and decreasing the side effects on the healthy cells (Maletínská et al., 2000; Pires et al., 2012; Radwan & Alanazi, 2014; Huang et al., 2015; Alhadad et al., 2020; Jaragh Alhadad, 2021). Here, LDLR is linked to cancer.