Here we show that the lncRNA MILIP forms an RNA-RNA duplex with the Snai1 mRNA that recruits Y-box binding protein 1 (YBX1) to facilitate YBX1-mediated translational activation of Snai1, which in turn promotes the EMT and metastasis of ccRCC cells. The gene discussed is SNAI1; the disease is nonpapillary renal cell carcinoma.