Moreover, Dox treatment of NOD/SCID mice that received tail vein injection of ACHN.shMILIP cells markedly reduced the formation of pulmonary metastatic lesions (Fig. 2i-l), demonstrating that MILIP promotes ccRCC metastasis in vivo, consistent with its role in regulating the EMT in ccRCC cells identified in vitro (Fig. 2g, h, Supplementary Fig. 2f, g). Here, MILIP is linked to nonpapillary renal cell carcinoma.