For example, the lncRNA c-Myc-inducible long noncoding RNA inactivating p53 (MILIP), also known as v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G (MAFG) antisense RNA1 (MAFG-AS1), represses the tumor suppressor p53 and promotes tumorigenesis in diverse cancer types, whereas the lncRNA pan-cancer lncRNA activating NCOR2 responsive to E2F1 (PLANE), also known as melanotransferrin antisense RNA 1 (MELTF-AS1 or MFI2-AS1), regulates an alternative splicing program to promote cancer pathogenesis similarly in the pan-cancer context [19, 20]. The gene discussed is E2F1; the disease is cancer.