IGF2 and nonpapillary renal cell carcinoma: For instance, while the lncRNA up-regulation in clear cell renal cell carcinoma (URRCC) promotes ccRCC cell proliferation and invasion through promoting the expression of epidermal growth factor-like protein 7 (EGFL7), the lncRNA DNA methylation–deregulated and RNA m6A reader–cooperating (DMDRMR) stabilizes insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) target genes to facilitate ccRCC growth and metastasis [21, 22].