TP53 and osteosarcoma: Bhargava et al. [118] stated that the isolated artepillin C from Brazilian green propolis abrogated mortalin-p53 complex, causing the activation of p53 and the growth arrest of cancer cells at 275 μM concentration in HT1080 (fibrosarcoma), A549 (lung carcinoma) and U2OS (osteosarcoma) human cell lines.