ALDH2 and esophageal cancer: Looking at ADH1B * 1 / * 1 alone, the risk of esophageal cancer in drinkers was 2.71–3.22 times higher; however, the combination of ADH1B * 1 / * 1 and ALDH2 * 1 / * 2 had 12.45 times higher risk [11].