Down-regulated miR-146a levels in PBMCs has been demonstrated in SLE, negatively associated with increased IL-6/IL-8 and TRAF6 expression, particularly in renal involvement; however, miR-146a levels were up-regulated in USCs and glomerular tissues from LN [9, 31]. The gene discussed is CXCL8; the disease is systemic lupus erythematosus.