Recently, lots of efforts have been made to develop small-molecule drugs including Porcupine (PORCN) Inhibitor,Tankyrase Inhibitors,TCF/β-Catenin Complex Inhibitors,CBP/β-Catenin Inhibitors,BCL9/β-Catenin Inhibitors,Natural Compounds Target Wnt Signaling Pathway,Challenges to Inhibiting the Wnt/β-Catenin Pathway,to inhibit the WNT pathway for the treatment of many types of cancers[43]. Here, HNF4A is linked to cancer.