In this study, using the expression data of HCC from TCGA database and the list of 161 ARGs from GSEA, a novel apoptosis-related signature prognostic-predictive model composed of nine genes (CDC25B, DAP3, ETF1, GSR, LGALS3, MGMT, PPP2R5B, SQSTM1 and VDAC2) was identified in HCC. The gene discussed is CDC25B; the disease is hepatocellular carcinoma.