TM6SF2 and cryohydrocytosis: In view of the above, the present study explores the association of PNPLA3 p.I148M (rs738409) and TM6SF2 p.E167K (rs58542926) single nucleotide polymorphisms (SNPs) with predisposition to liver scarring in a geographically novel cohort (Pakistani CHC patients) employing independent and adjusted analyses for common confounders of demographic, viral, laboratory and clinical nature that may influence this association.