PNPLA3 and cirrhosis of liver: Second, diabetes mellitus status (a known significant risk factor for the development of liver cirrhosis in CHC patients), including any Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) data, was not available and hence, regression models analyzing association of PNPLA3 and TM6SF2 variants were not adjusted for any potential effects of diabetes mellitus status, which adds to the limitations of this study.