TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Similarly, TM6SF2 rs58542926 variant has been reported to associate with increased risk of NAFLD [14], where the minor (T) allele of this missense variant reportedly conferred TM6SF2 functional loss, translating to enhanced aggregation of intrahepatic lipids due to diminished very low density lipoprotein (VLDL) secretion [15].