In this context, PNPLA3 rs738409 polymorphism has been found associated with liver fat content [7], as well as with clinical phenotypes of steatosis, steatohepatitis and liver fibrosis/cirrhosis in various hepatic etiologies of non-viral [mainly NAFLD and alcoholic liver disease (ALD)] [8, 9] and viral (mainly CHC) [10, 11] origins. The gene discussed is PNPLA3; the disease is cryohydrocytosis.