PNPLA3 and metabolic dysfunction-associated steatotic liver disease: PNPLA3 rs738409 and TM6SF2 rs58542926 SNPs, that initially came into highlight from GWAS [5] and EWAS [6] analyses in patients with NAFLD, are important modulators of hepatic fat metabolism and are regarded as significant genetic influencers of liver injury of various etiologies especially steatosis and NAFLD.