Next, potential risk factors that may be associated with liver fibrosis and cirrhosis were analyzed using logistic regression models, as summarized in Table 5 and Additional file 3: Supplementary Table 3, the results of which suggest no significant associations of PNPLA3 p.I148M and TM6SF2 p.E167K genotypes with liver fibrosis stages or cirrhosis in univariate and multivariate regression models (all p =  > 0.05). The gene discussed is PNPLA3; the disease is Cirrhosis.