In view of the above, the present study explores the association of PNPLA3 p.I148M (rs738409) and TM6SF2 p.E167K (rs58542926) single nucleotide polymorphisms (SNPs) with predisposition to liver scarring in a geographically novel cohort (Pakistani CHC patients) employing independent and adjusted analyses for common confounders of demographic, viral, laboratory and clinical nature that may influence this association. Here, PNPLA3 is linked to cryohydrocytosis.