Indeed, the association of PNPLA3 rs738409 and TM6SF2 rs58542926 SNPs with hepatic injury resulting from dysregulation of hepatic lipid metabolism (steatohepatitis and NAFLD) is well established [5, 6, 8, 17, 28], however, extension of their implication in NAFLD-associated hepatic fibrosis is not definite [28] and is certainly debatable in the context of hepatic fibrosis and cirrhosis of viral (especially CHC) etiology [10, 17, 29, 30]. Here, PNPLA3 is linked to cryohydrocytosis.