The dawn of genome-wide association study (GWAS) approach highlighted the potential role of host genetic factors related to hepatic fat metabolism [including PNPLA3 (adiponutrin or patatin-like phospholipase domain-containing protein 3) and TM6SF2 (transmembrane 6 superfamily member 2) in CLP, mainly in non-alcoholic fatty liver disease (NAFLD) settings [5, 6]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.