GOPC and spermatogenic failure 16: GOPC and VPS54 are important constituent proteins in the Golgi apparatus in tissue culture cells, and knockout mice of the VPS54 or GOPC genes presented abnormal acrosome formation [43–46] Li L et al. confirmed that the expression of Golgi-related genes was upregulated, including GOPC and VPS54, in a patient with acephalic spermatozoa syndrome, suggesting a relationship in the pathology between acephalic spermatozoa and abnormal acrosome formation [20]; our data support their inference.