After 12 weeks on a HF diet, the epidydimal-WAT (eWAT), inguinal-WAT (iWAT), brown adipose tissue (BAT) mass and adipocyte size were significantly lower in Klhl3−/− (2in) male mice than in control mice (Fig. 1c, d and Supplementary Fig. 3a–c). The gene discussed is KLHL3; the disease is hydrops fetalis.