Gordon syndrome (also called pseudohypoaldosteronism type II, PHAII) is a rare monogenic disease resulting from mutations to WNK1, WNK4, CUL3, and KLHL3. Takayhashi et al. reported that WNK4 is an adipogenic factor and that its deletion reduces diet-induced obesity in mice16; however, there have been no reports of a correlation between PHAII and the phenotype for obesity resistance in humans. This evidence concerns the gene CUL3 and obesity due to melanocortin 4 receptor deficiency.