Our MDS-RS model exhibited mis-splicing–associated downregulation of MAP3K7 (Figs. 2c, d, 3b), which was confirmed in K562 cells overexpressing SF3B1K700E (Fig. 4a, b and e) and SF3B1MUT-MDS patients (Fig. 7a and c). Here, MAP3K7 is linked to myelodysplastic syndrome.