Although exhibition of RS formation in the SF3B1G742D-MDS-RS model cell has been reported21, the establishment of an MDS-RS model harboring SF3B1K700E is desirable because MDS with the SF3B1K700E mutation was reported to be different from MDS with other SF3B1 mutations in terms of splicing pattern and prognosis22. This evidence concerns the gene SF3B1 and myelodysplastic syndrome.