In a study that analysed immune parameters in relation to fatigue in patients with clinically quiescent IBD, systemic concentrations of pro-inflammatory cytokines IFN-γ, TNF-α, IL-12 as well as numbers of memory T-cells and neutrophils were higher among fatigued patients, whereas IL-6 and monocyte concentrations were lower14. Here, TNF is linked to inflammatory bowel disease.