The other type of assembly forms smaller N- and C-terminally truncated protease-resistant fragments (typically 7–15 kDa, derived from the central region of PrP) and is associated with prominent PrP amyloid plaques that are commonly seen in some inherited prion diseases (Giaccone et al. 1992; Piccardo et al. 1996, 1998, 2001; Parchi et al. 1998; Salmona et al. 2003; Hill et al. 2006; Wadsworth et al. 2006; Monaco et al. 2012; Asante et al. 2013, 2020; Ghetti et al. 2018; Cracco et al. 2019). Here, PRNP is linked to amyloidosis.