WNK2 and infection: However, structural modelling in Phyre2 Server27 suggested the C-terminus of KinC (143-229 AA residues) belongs to HopA1 superfamily including phosphothreonine lyases from various Gram-negative pathogens, such as OspF from Shigella fexneri28, which irreversibly removes phosphate groups from phosphothreonine in the activation loop of mitogen-activated protein kinases in the host cells during the pathogen infections.