As deregulated expression of SerpinE1 has been found in several age-associated metabolic diseases [28] as well as in HGPS-associated pathological events, such as thrombosis [29] and atherosclerosis [30], it is tempting pointing to SerpinE1 upregulation as a key event in HGPS development and progression. This evidence concerns the gene SERPINE1 and atherosclerosis.