SERPINE1 and Hutchinson-Gilford progeria syndrome: Our RNA-seq analysis in primary fibroblasts derived from HGPS patients (as compared to their healthy counterpart) has identified SerpinE1 upregulation and functional activation as a key mediator of a reciprocal signaling between nuclear lamina and aberrant activation of pathogenic events that contribute to the disease development, including constitutive DNA damage, mitochondrial defects and expression of pro-fibrotic genes.