Lymphatic vascularization is a hallmark of both AML and LAM, AML cells can metastasize to regional lymph nodes, and it has been proposed that LAM cells metastasize to the lungs from a distant unknown site-of-origin24,109 VEGFD is thought to promote lymphangiogenesis and lymphatic metastasis24. Here, VEGFD is linked to lymphangioleiomyomatosis.