CD8A and neoplasm: Re-clustering of tumor-derived CD8+ T cells (downsampled to have equal number of cells from SLS or IS samples) revealed three major clusters: memory/naive T cells (CD8 Tm/naive), effector T cells (CD8 Teff) and proliferating T cells (CD8 T-prolif), as well as subclusters within each major cluster, with different expression of immune checkpoint genes or cytotoxic effector genes (Fig. 5a, b).