These AML-derived macrophages showed higher expression of the immune checkpoint genes T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) encoded by HAVCR2, and V-domain immunoglobulin suppressor of T-cell activation (VISTA) encoded by VSIR, in comparison to macrophages derived from matched normal kidneys (Fig. 6b). Here, HAVCR2 is linked to acute myeloid leukemia.