Because TREM2+/TYROBP+ tumor-infiltrating macrophages inhibit T-cell proliferation in animal models of sarcoma, colorectal cancer, and mammary tumor96,97, it is possible that these suppressive macrophages are responsible for the observed T-cell dysfunction and almost complete suppression of T-cell clonal expansion and differentiation observed in SLS-dominant tumors. This evidence concerns the gene TYROBP and colorectal cancer.