Specific genes of interest include MDK (newly identified here as highly expressed in AML) and GPNMB (a known marker of AML50), both of which are increased in AML cells in both the scRNA-Seq dataset (Fig. 1g) and the bulk RNA-seq dataset of tumor samples8 (Supplementary Fig. 3e). This evidence concerns the gene GPNMB and acute myeloid leukemia.