Besides AML cells (as described above), the cluster also contains tumor-associated fibroblasts (TAF) with no expression of tumor marker genes but high expression of known TAF marker genes: Tumor-Derived Adhesion Factor (IGFBP7)31, Fibroblast-Specific Protein-1(FSP1/S100A4)32, Platelet-Derived Growth Factor Receptor Beta (PDGFRB)32, Secreted Protein Acidic And Rich in Cysteine (SPARC), and SPARC-Like Protein 1 (SPARCL1) (Fig. 1f, Supplementary Fig. 3a). The gene discussed is IGFBP7; the disease is acute myeloid leukemia.