B2M and acute myeloid leukemia: We observed numerous interactions in SLS-dominant tumors, including B2M-HLA-F, HLA-B-CANX, and MIF-CD74 in B and T cells (Fig. 7g and Supplementary Fig. 10d, e), similar to what has been reported for melanoma86, which is of interest because as described above, AML express many melanoma marker genes including MITF, PMEL, and MLANA46,47.