PRKAA2 and pulmonary arterial hypertension: When taken together these data provide indirect support for the view that right ventricular myopathy of AMPK-α1/α2 knockouts is likely driven, at least in part, by the onset of pulmonary hypertension after birth (see Discussion for further details), a view that gains further indirect support from the fact that we found no evidence of differences in either blood vessel number (n = 5; Note, two-sided unpaired Mann–Whithney P = 0.056) or medial thickness (n = 5) for the right ventricle of AMPK-α1/α2 knockouts when compared to controls (Supplementary Fig. 13).