RYBP and B-cell non-Hodgkin lymphoma: To ensure that RYBP-mediated repression of lytic viral genes is not cell type specific, we also tested the effect of RYBP on viral gene expression during de novo KSHV infection in 293T epithelial cells and EA.hy926 endothelial cells as well as in latently infected KSHV+ B cell lymphoma cells (BCBL1) (S2 Fig).