The analysis of Guo and colleagues dataset showed that Hyp proteins up-regulated in kidney cancer were strongly enriched in KEGG pathways including ECM-receptor interaction, focal adhesion, glyoxylate/dicarboxylate metabolism, and tryptophan metabolism (S10D Fig), while pathways including biosynthesis of amino acids, fructose/mannose metabolism, pathgenic E. coli infection and PI3K-Akt signaling were significantly enriched among down-regulated Hyp proteins in tumor tissue (S10E Fig) (BH corrected FDR < 0.05). The gene discussed is PHEX; the disease is kidney cancer.