TARDBP and amyotrophic lateral sclerosis: For example, nuclear-import receptor chaperones can inhibitphase separation of RNA-binding proteins.3,4 Inaddition, the heat shock chaperones HSP70 and HSP27 maintain the liquidityof condensates formed by the amyotrophic lateral sclerosis (ALS)/frontotemporaldementia (FTD)-associated proteins TDP43 and FUS, while a proteindisulfide isomerase was shown to repress LLPS and modulate the aggregationof the Alzheimer’s disease-associated protein tau.5−7 Molecular chaperones thus might protect proteins from misfoldingand pathogenic aggregation inside cellular condensates.