Therefore, we investigated the effects of the noncompetitive P2Y6 receptor antagonist, MRS2578 (1 μM), a concentration that is ten times higher than the IC50 (98 nM) obtained at the P2Y6 receptor expressed in 1321N1 astrocytoma cells [31]. This evidence concerns the gene P2RY6 and astrocytoma (excluding glioblastoma).