Based on the HER2 scoring system for gastric (Ruschoff et al. 2012) and breast cancer (Rakha et al. 2015), FISH HER2-positive status was defined as HER2/CEP17 ≥ 2.0 or/and a mean HER2cn ≥ 6.0. Here, ERBB2 is linked to breast carcinoma.