Interestingly, more evidence seems to support that palmitoylation enhances apoptosis in CRC, the death receptors 4 (DR4) palmitoylation enhanced its lipid rafts localization in oxaliplatin resistance CRC cell lines, which enhanced tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) sensitivity and bind to DR4, thereby inducing cell apoptosis [47, 48]. This evidence concerns the gene TNFSF10 and colorectal carcinoma.