[75] developed an amphiphile‐mediated depalmitoylation (AMD) strategy using C8 alkyl cysteine, to cleave S‐palmitoyl groups from endogenous membrane‐associated NRAS protein, resulting in a significant reduction in NRAS palmitoylation, inhibition of NRAS signaling, as well as melanoma progression (Table 1). Here, NRAS is linked to melanoma.