LYPLA1 and B-cell chronic lymphocytic leukemia: Therefore, knockdown of APT1 and APT2 with siRNA or pharmacological inhibition of APT1 and APT2 using Palm‐B, or overexpressing miRs‐138/‐424 to deregulate and target APT1 and APT2, restores CD95‐mediated apoptosis in chronic lymphocytic leukemia cells [121].