LYPLA1 and cancer: Similarly, knockdown of depalmitoylating enzyme APT1 (also known as LYPLA1) with shRNA in MDA‐MB‐231 cells depleted a specific subpopulation of tumorigenic cells, resulting in colony formation being suppressed [120], which may be related to the increased apoptosis of cancer cells mediated by CD95 (Fas/APO‐1) [121] (Table 1).