Moreover, ZDHHC18‐medited palmitoylation of malate dehydrogenase 2 (MDH2) at Cys138 is essential for mitochondrial respiration and ovarian cancer cell proliferation both in vitro and in vivo, and loss of MDH2 palmitoylation by mutating the palmitoylation site or knocking down of ZDHHC18 with shRNA inhibited the clonogenic capability of ovarian cancer cells [14]. This evidence concerns the gene MDH2 and ovarian cancer.