ZDHHC19‐mediated SMAD family member 3 (Smad3) palmitoylation at Cys421 enhances activation of the transforming growth factor (TGF) signaling pathway, and Smad3 interaction with E1A binding protein P300 (EP300) promotes mesenchymal‐like transition in the mesenchymal subtype of glioblastoma (GBM) [86]. The gene discussed is SMAD3; the disease is glioblastoma.