In addition, a mono‐palmitoylated peptide that contained the dominant MHC class‐I and II epitopes of the human melanoma antigen gp100 (gp100280‐288/45‐59) or the mouse model antigen ovalbumin (OVA257‐264/323‐339) conjugated to palmitolate anhydride (C16:0) was developed that is efficiently internalized by DCs and subsequently cross‐presented to CD8+ T‐cells, ultimately inhibiting melanoma progression [134] (Table 1). The gene discussed is CD8A; the disease is melanoma.