The methylation of the CNBP gene has been analyzed using a pyrosequencing method, revealing hypomethylation of CpG sites upstream and hypermethylation of CpG sites downstream of the (CCTG)n expansion in DM2 patients and healthy individuals, with no significant differences between these groups (Santoro et al., 2018). This evidence concerns the gene CNBP and myotonic dystrophy type 2.