Therefore, it is important to use ACF in order to inhibitnot only TLR3 signaling but also HIF-1, leading to increased effectivenessin breast cancer treatment.98 Melanomacan also activate hypoxia response pathways even under normoxic conditions,indicating the participation of HIF-1α enabling survival underoxidative stress.99 The influence of ACFon the metabolism and progression of melanoma under normoxic conditionswas described (Figure 7).10 It was proven that inhibition ofHIF-1α with ACF in melanoma can be an effective cure againstthis tumor, regardless of the tumor’s hypoxic state. The gene discussed is HIF1A; the disease is melanoma.