Activation of the major hypoxicfactors (HIF-1) supports the creation of a cancer-promoting microenvironment.Hypoxia mainly affects solid tumors; however, pancreatic cancer differsfrom most solid tumors in its high stromal content, and thereforeit is characterized by a particular hypoxia and is able to survivein a changed microenvironment thanks to the mechanisms of interactionbetween pancreatic cancer cells and stromal cells and the activationof many signaling pathways, such as AKT, STAT3, and ERK.41 This evidence concerns the gene AKT1 and pancreatic neoplasm.