Consistent with the HPA database, the expression of AHNAK2 was significantly higher in adenocarcinomas than in normal gland tissues (breast cancer:n=40,P<0.01;Figure 3A,B andSupplementary Figure S3E; colon cancer:n=90,P<0.01;Figure 3C,D andSupplementary Figure S3F; and esophageal squamous:n=12,P<0.01;Figure 3E,F andSupplementary Figure S3G). Here, AHNAK2 is linked to colonic neoplasm.