Through microarray and immunohistochemical (IHC) analyses of a variety of tumor tissues, we find that among these 20 genes,AHNAK2 is highly expressed not only in cervical adenocarcinoma, but also in multiple of adenocarcinoma tissues, including esophagus, breast and colon, while not in normal gland tissues.In vitro,AHNAK2 knockdown significantly inhibits cell proliferation and migration of adenocarcinoma cell lines.In vivo,AHNAK2 knockdown significantly inhibits tumor progression and metastasis of various adenocarcinomas. The gene discussed is AHNAK2; the disease is neoplasm.