19). This phenomenon is more common in larger venous vessels at lower shear rates, such as in the lower limbs, which indeed are an elective site of venous thrombosis (Ref. 20). Notably, fibrinogen is essential for the formation of rouleaux under low shear conditions (Ref. 21) as it is able to bridge nearby cells, stimulating aggregates formation; the connection between fibrinogen and erythrocytes seems to be mediated by an integrin receptor on erythrocytes membrane, the β3 integrin (Ref. 22) and/or the integrin-associated protein (CD47) (Ref. 23). The gene discussed is CD47; the disease is Venous thrombosis.