In line with the tendency we observed in the full study sample, some of the studies reported higher plasma RBP4 concentrations with lower risk of stroke in women,12 CVD mortality in diabetic men,48 and coronary artery diseases.11 Only one study reported a nonsignificant interaction test with hypertension state.12 However, this study was considerably smaller than ours (ncases=471, ncontrols=471) with limited power to detect statistically significant interactions. This evidence concerns the gene RBP4 and coronary artery disorder.