VCX3A and hypogonadotropic hypogonadism: Moreover, low expression of the VCX3A gene was reported in infertile cryptorchid males,52 and deletion of a region including this gene was noted in cases with congenital hypogonadotropic hypogonadism,78 which indicates that the identified variant may also be associated with spermatogenesis disruption, leading to azoospermia.