QKI and neoplasm: Iwata et al. (2017) demonstrated that gene expression of QKI was significantly down-regulated in CRC tissues (p = 0.049), and patients with low tumor QKI expression were associated with worse prognoses (n = 153). In contrast, our survival analysis based on the TCGA CRC dataset (n = 361) and our in-house validation dataset (n = 246) did not suggest a significant association between the methylation level of the QKI promoter and the overall survival of CRC (Supplementary Figure S6).