YTHDF1 and hepatocellular carcinoma: Lin et al. (2019) found that Snail was methylated in the CDS region and that YTHDF1 was significantly enriched in the CDS region of Snail mRNA leading to increased TGF-β-induced snail expression in HeLa cells. In addition, YTHDF1 silencing significantly increased the expression levels of Claudin-1 and zonula occludens protein 1, whereas expression of matrix metalloproteinase-9, matrix metalloproteinase-2, Vimentin, and N-cadherin was inhibited. These findings indicated that YTHDF1-mediated EMT is responsible for promoting the migration and invasion of HCC cells (Luo et al., 2021).