Huo et al. (2021) reported that YTHDF1 promoted upregulation of SPHK2 expression at the protein level via its specific structural domain, whereas SPHK2 coupled with KLF2 to induce phosphorylation modifications, thereby mediating KLF2 degradation and promoting the antiapoptotic function of GC cells. The gene discussed is SPHK2; the disease is gastric cancer.