Furthermore, YTHDF1 knockout reduced the translation efficiency of m6A-modified Keap1 transcripts, resulting in activation of the antioxidant oxygen radical scavenging system (Nrf2-AKR1C1) and resistance of NSCLC to cisplatin chemotherapy, leading to a worse clinical prognosis. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.