Lomholt et al. conducted a meta-analysis on the subject and concluded that raised hs-CRP did not predict an increase in mortality in patients with COPD [13], which was refuted by Luezzi et als who proposed, in their meta-analysis, that there was an increased possibility of death showing a positive statistical relationship between raised CRP levels and increased mortality (hazard ratio (HR) = 1.53, 95% confidence interval (CI) = 1.32-1.77) [14]. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.