Gallego et al. proposed that raised CRP in acute exacerbation is associated with certain types of bacterial pneumonia complicating COPD and predictive of increased requirements for hospital admission, intensive care, and more extended in-hospital stay. However, Leuzzi et al. disagreed with these findings and demonstrated that the relationship between raised CRP and early mortality was relatively weak [14]. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.