Earlier meta-analyses [16,17] with a substantial number of studies have also shown the significant relationship between C677T variation of the MTHFR gene and increased risk of ischemic stroke (Table 1). However, earlier meta-analyses had limitations to obtain the precise estimate of risk associated with MTHFR gene polymorphism for the risk of ischemic stroke. The gene discussed is MTHFR; the disease is ischemic stroke.