Regarding the risk of HP infection and gastric cancer, it has been suggested that HP seronegative category should be further classified into “negative-high titer” (for those with anti-HP antibody titer between 3 and 9.9 U/mL) and “negative-low titer” (for those with anti-HP antibody titer of <3 U/mL) [8]. This evidence concerns the gene HP and gastric cancer.