The mechanisms of BOLA2 regulation are as follows: (i) specific in-frame fusion transcript regulation [31], (ii) monothiol CGFS glutaredoxin binding partners, (iii) GRX3-dependent anamorsin maturation pathway [32], and (iv) as c-Myc-regulated gene in HCC [10]. The gene discussed is GLRX3; the disease is hepatocellular carcinoma.